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Automated exploration and exploitation of flow-injection response surfaces

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dc.contributor.author Wadell, A.P
dc.contributor.author Shiundu, P.M
dc.contributor.author Wentze, P.D
dc.date.accessioned 2015-05-21T14:57:48Z
dc.date.available 2015-05-21T14:57:48Z
dc.date.issued 1990
dc.identifier.citation Analytica Chimica Acta Volume 237, 1990, Pages 361–379 en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/pii/S0003267000839409
dc.identifier.uri http://hdl.handle.net/123456789/1028
dc.description.abstract Three-dimensional plots of instrumental responses vs. chemical concentrations or flow parameters have been 1 obtained in an automated manner on a computer-controlled flow-injection methods development system. Consideration of several alternative responses for flow-injection systems is shown to help characterize a chemistry more thoroughly and reveal the best experimental conditions. One may see the effects of individual experimental variables (reagent concentrations, pH, flow-rates, etc.), the interactions of these variables, instrumental factors and limitations of the surface exploration procedure employed. Chemical systems studied were the photometric determination of phosphate, palladium(II), iron(II) and persulfate. The propriety of automated response surface mapping is demonstrated and the efficacies of simplex and grid search approaches to response surface exploration are contrasted. Responses obtained include absorbance at peak maximum, relative standard deviation of maximum absorbance, time from injection to peak maximum and wavelength of maximum absorbance. Higher dimensional response surface representations of peak shape and absorbance spectra are also presented. The results show that the response chosen governs the general shape of the surface and the height at any point. This approach to automated characterization of chemical reactions in flow analysis is critically assessed en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Response surface mapping en_US
dc.subject Automated optimization en_US
dc.subject Simplex optimization en_US
dc.title Automated exploration and exploitation of flow-injection response surfaces en_US
dc.type Article en_US

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