Abstract:
Vitamin D can be derived from quite limited amount of foods, from exposing the skin to the sun or by supplementing with tablets. CHD is a common disease in the world with increased mortality from the early 20th century. Previous studies have investigated the association between vitamin D intake and CHD mortality. However, the results are inconclusive, indicating the need for continued research.
Vitamin D intake of 415 patients with CHD were analyzed to predict CHD mortality. During the 5 year follow up, there were 16 CHD deaths. After adjusting for age and sex there was no association between vitamin D intake and CHD death with RR 1.10 (95% confidence interval (CI) 1.04-1.17,p= 0.677), CVD death, 1.07 ( 95% CI 1.02-1.12, p=0.578), and total death RR 1.05( 95% CI 1.00-1.10, p=0.266.
The association remained insignificant after further adjustment for known confounders. There was no association between different groups of vitamin D intake and the three endpoints: total, CVD and CHD mortality (p for trend across groups: 0.30, 0.74 and 0.89, respectively). After adjustment for age, gender and other confounders, those in the vitamin D group of 5-7 μg/day had RR of 1.27 (95% CI: 0.52,3.12) of total death, compared to those in the lowest group of < 5 μg/day (p for trend across groups: 0.30).
Results from this study suggest that there is no association between vitamin D intake and CHD mortality in subjects with existing CHD . The clinical implication of this study is that vitamin D intake among men and women with CHD could benefit from further research.
