School of Pure and Applied Sciences

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Browsing School of Pure and Applied Sciences by Author "KAPTICHIUP, RONO GEOFFREY"

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    COMPARISON OF PERCENTAGE CONTENT OF THE ACTIVE INGREDIENTS BETWEEN ORIGINAL AND GENERIC FANSIDAR TABLETS CIRCULATING IN KENYA MARKET
    (2019-04-08) KAPTICHIUP, RONO GEOFFREY
    rour samples of fansidar tablets collected florn various chemist shops around Nairobi area were analysed to check the percentage content of the active ingredients. Samples one, two and three were generics (Drugs manufactured by other manufacturers aner having consent froll1 the mother compony) while saillple four was original (drug manufactured by a company which first started manufacturing it). A standard was prepared in the same way as the samples for comparison. Once a sample and a standard are injected in High pressure liquid chromatography (H.I)L.C) machine alternatively, they rroduce peak 's areas as shown in appendices 1,11,111 and IV The peak' s areas of the standard are compared with the peak's areas of the sample. Since the concentration of the standard is known, the concentration of the sample is then got by comparison taking il1to (ICCOUllt the dilutions madc. Theil the result is divided by the label claim (What the manufacturer is claiming the drug to contain for intance in this case, each uncoasted tablet contains sulfadoxine USP 500 mg and pyrimethamine USP 25 lIlg). To get percentages, the result is eventually multiplied by 100% as shown ill chapter three.