Regioselective Synthesis of a Branched Isomer of Nonylphenol, 4-(3′,6′-Dimethyl-3′-heptyl)phenol, and Determination of its Important Environmental Properties

Lalah, Joseph OSchramm, Karl-WernerLenoir, DieterHenkelmann, BernhardHertkorn, NorbertKettrup, AntoniusGünther, Klaus2015-06-022015-06-022001Chemistry - A European Journal Volume 7, Issue 22, pages 4790–4795, November 19, 2001http://onlinelibrary.wiley.com/doi/10.1002/1521-3765%2820011119%297:22%3C4790::AID-CHEM4790%3E3.0.CO;2-L/fullhttp://hdl.handle.net/123456789/1257A method for the synthesis of a pure nonylphenol isomer, 4-(3′,6′-dimethyl-3′-heptyl)phenol, by Friedel–Crafts reaction between anisole and 3-bromo-3,6-dimethylheptane that gives a 47.3 % overall yield is reported. The reactions were followed by GC-MS, and the chemical structures are in agreement with the NMR and IR spectra. The log Kow value for this compound, its water solubility, vapor pressure, and Henry's Law constant were also determined. These physicochemical properties were required for prediction of the compound's behavior in aquatic ecosystems.enEnvironmental chemistryFriedel–Crafts alkylationNonylphenol isomerSynthesis designRegioselective Synthesis of a Branched Isomer of Nonylphenol, 4-(3′,6′-Dimethyl-3′-heptyl)phenol, and Determination of its Important Environmental PropertiesArticle