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Biological cost of tolerance to heavy metals in the mosquito Anopheles gambiae

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dc.contributor.author Mireji, PO
dc.contributor.author Keating, J
dc.contributor.author Hassanal, A
dc.contributor.author Mbogo, CM
dc.contributor.author Muturi, MN
dc.contributor.author Githure, JI
dc.contributor.author Beier, JC
dc.date.accessioned 2015-05-28T14:25:05Z
dc.date.available 2015-05-28T14:25:05Z
dc.date.issued 2010
dc.identifier.citation Medical and Veterinary Entomology Volume 24, Issue 2, pages 101–107, June 2010 en_US
dc.identifier.issn http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2915.2010.00863.x/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false
dc.identifier.uri http://hdl.handle.net/123456789/1144
dc.description.abstract The global rate of heavy metal pollution is rapidly increasing in various habitats. Anopheles malaria vector species (Diptera: Culicidae) appear to tolerate many aquatic habitats with metal pollutants, despite their normal proclivity for ‘clean’ water (i.e. low levels of organic matter). Investigations were conducted to establish whether there are biological costs for tolerance to heavy metals in Anopheles gambiae Giles sensu stricto and to assess the potential impact of heavy metal pollution on mosquito ecology. Anopheles gambiae s.s. were selected for cadmium, copper or lead tolerance through chronic exposure of immature stages to solutions of the metals for three successive generations. Biological costs were assessed in the fourth generation by horizontal life table analysis. Tolerance in larvae to cadmium (as cadmium chloride, CdCl2), copper [as copper II nitrate hydrate, Cu(NO3)2 2.5 H2O] and lead [as lead II nitrate, Pb(NO3)2], monitored by changes in LC50 concentrations of the metals, changed from 6.07 µg/L, 12.42 µg/L and 493.32 µg/L to 4.45 µg/L, 25.02 µg/L and 516.69 µg/L, respectively, after three generations of exposure. The metal-selected strains had a significantly lower magnitude of egg viability, larval and pupal survivorship, adult emergence, fecundity and net reproductive rate than the control strain. The population doubling times were significantly longer and the instantaneous birth rates lower in most metal-selected strains relative to the control strain. Our results suggest that although An. gambiae s.s. displays the potential to develop tolerance to heavy metals, particularly copper, this may occur at a significant biological cost, which can adversely affect its ecological fitness. en_US
dc.language.iso en en_US
dc.subject Anopheles gambiae en_US
dc.subject Biological cost en_US
dc.subject Cadmium en_US
dc.subject Copper en_US
dc.subject Heavy metals en_US
dc.subject Lead en_US
dc.subject Tolerance en_US
dc.title Biological cost of tolerance to heavy metals in the mosquito Anopheles gambiae en_US
dc.type Article en_US

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