A hallmark of ulcerative colitis is the chronic colonic inflammation, which is the result of a dysregulated intestinal mucosal immune response. Epithelial barrier disruption which allows the entry of microorganisms eventually ...
Otieno-Odhiambo, Patricia; Schwartz, Ilan S.; Lerm, Barbra; Hoving, J. Claire(2018-02)
The newly described thermally dimorphic fungal genus Emergomyces comprises human pathogens that cause systemic mycoses in immunocompromised persons globally (1). Among these fungi, Emergomyces africanus (formerly Emmonsia ...
Abstract
Background: Conventionally, human monocyte sub-populations are classified according to surface marker expression into classical (CD14++CD16−), intermediate (CD14++CD16+) and non-classical (CD14+CD16++) lineages. ...
Otieno-Odhiambo, Patricia; Wasserman, Sean; Hoving, J. Claire(mdpi, 2019-04-19)
Abstract:
Pneumocystis is a ubiquitous atypical fungus that is distributed globally. The genus comprises morphologically similar but genetically heterogeneous species that have co-evolved with specific mammalian hosts ...
Osano, Hezron Mogaka(Journal of Innovation and Entrepreneurship, 2019-12)
Abstract
There is need for Kenyan small and medium enterprises (SMEs) in particular to focus concern on the orientation of business strategy toward global market strategy, market research geared at obtaining foreign market ...
Osano, Hezron Mogaka; Languitone, Hilario(Journal of Innovation and Entrepreneurship, 2016-03)
Abstract
SMEs play an important role in the economic development of Mozambique. Access to finance is important for the growth of SMEs. Thus, the purpose of the study was to establish the factors that influence access to ...
Kanyua, Esther Kiruja; Otieno, Jillient(Journal of Human Resource Management, 2022-04)
ABSTRACT
Psychological contracts are acceptable and unregistered, so they do not need be distributed on the other side of the exchange. The use of Psychological contracts creates a sense of audit, enhances trust and has ...
Orina, Alfred Isaac; Mutua, Mutuku Joseph; Adawo, Onjong Hillary; Wanjiru, Mwaniki Mercy; Reagan, Vuluku; Venessa, Muchai(International Journal of Food Science and Biotechnology, 2020-11-09)
Abstract: Background: Exposure to heavy metals (Pb and Cd) through diet posses a significant risk to human health. Areas of Mlolongo, Athi River and Syokimau are surrounded by industries, which dispose off their waste water ...
Orina, Alfred Isaac; Musasia, Fauzia K; Masiga2, Daniel K; Omedo, Irene A; Mwakubambanya, Ramadhan; Ochieng, Richard; Mireji, Paul O(Malaria Journal, 2013-05)
Abstract
Background: Anopheles gambiae, one of the main Afro-tropical mosquito vector of malaria, has adapted to heavy metals in its natural habitat, and developed resistance to most conventional insecticides. Investigations ...
Orina, Alfred Isaac; Nyariki, James Nyabuga; Thuita, John Kibuthu; Nyambati, Grace Kemunto(Journal of Coastal Life Medicine, 2014-03-14)
Objective: To establish the modulatory effects of coenzyme Q10 on experimental trypanosome itnrefeactmtioennst riena cmtiivcee eanncde epvhaalluoaptaet hthy e(P rTiRskE )o.f occurrence and severity of melarsoprol-induced ...
Cerebral malaria is a complex neurological syndrome, whose pathology is mediated by inflammatory processes triggered by the immune system of the host following infection with P. falciparum. Coenzyme Q10 (CoQ10) is an ...
Orina, Alfred Isaac; Dukhande, Vikas V.; Lai, James C. K.(Springer Science, 2007-06-12)
Abstract Oxidative stress can induce mitochondrial dysfunction, mitochondrial DNA (mtDNA) depletion, and neurodegeneration, although the underlying mechanisms are poorly understood. The major mitochondrial antioxidant ...
Ongore, Vincent O.; Zainabu, Ramadhan; Oloko, Margaret(International Journal of Economics, Commerce and Management, 2017-11)
Abstract
The use of horizontal alliance among insurance firms creates internal capital markets that substitute for well-developed external capital and corporate debt markets. Furthermore, the risk sharing and pooling ...
Orina, Alfred Isaac; Malthankar-Phatak, Gauri H.; Patel, Anant B.(nATIONAL iNSTITUTE OF hEALTH, 2008-10)
Abstract
Mechanisms underlying hypoxia-induced neuronal adaptation have not been fully elucidated. In the present study we investigated glucose metabolism and the activities of glycolytic and TCA cycle enzymes in ...
Orina, Alfred Isaac; Vikas, V.; Lai, James C. K.(Springer Science, 2007-06-12)
Abstract Oxidative stress can induce mitochondrial dysfunction, mitochondrial DNA (mtDNA) depletion, and neurodegeneration, although the underlying mechanisms are poorly understood. The major mitochondrial antioxidant ...
Abstract Peroxisome proliferator-activated receptors (PPARs) play roles in neural cells by regulating energy balance, cell proliferation and anti-oxidant responses
although the molecular mechanisms underlying such roles ...
Orina, Alfred Isaac; Koech, K. R.; Wachira, F. N.; Ngure, R. M.(AFRICAN JOURNAL OF AGRICULTURAL RESEARCH, 2013-05-23)
The tea polyphenols have been shown to possess many medicinal properties including antifungal activity, but there have been few studies regarding antifungal activity. The antifungal activity of tea polyphenols was evaluated ...
Orina, Alfred Isaac; Kennedy, Chepukosi; Okanya, Patrick; Nyariki, James Nyabuga(www.sciencedirect.com/science/journal/24058440, 2020-05-19)
Ethnopharmacological relevance: The consumption of khat (Catha Edulis, Forsk) is on the rise despite the much publicized associated deleterious health effects. How chemicals present in khat, affect various physiological ...
Orina, Alfred Isaac; Singh, Ajay; Luo, Xiu(PLOS Pathogens, 2009-03-13)
Abstract
Neurotoxicity in all prion disorders is believed to result from the accumulation of PrP-scrapie (PrPSc), a b-sheet rich isoform of a normal cell-surface glycoprotein, the prion protein (PrPC). Limited reports ...