• IL-4 Receptor-Alpha Signalling of Intestinal Epithelial Cells, Smooth Muscle Cells, and Macrophages Plays a Redundant Role in Oxazolone Colitis 

  Otieno-Odhiambo, Patricia; Hoving, Jennifer Claire; Keeton, Roanne; Höft, Maxine A.; Ozturk, Mumin; Brombacher, Frank (Hindawi, 2020-01-17)

  A hallmark of ulcerative colitis is the chronic colonic inflammation, which is the result of a dysregulated intestinal mucosal immune response. Epithelial barrier disruption which allows the entry of microorganisms eventually ...
• Emergomyces africanus in Soil, South Africa 

  Otieno-Odhiambo, Patricia; Schwartz, Ilan S.; Lerm, Barbra; Hoving, J. Claire (2018-02)

  The newly described thermally dimorphic fungal genus Emergomyces comprises human pathogens that cause systemic mycoses in immunocompromised persons globally (1). Among these fungi, Emergomyces africanus (formerly Emmonsia ...
• Quantitative whole-cell MALDI-TOF MS fingerprints distinguishes human monocyte sub-populations activated by distinct microbial ligands 

  Otieno, Patricia; Portevin, Damien; Pflüger, Valentin; Brunisholz, René; Vogel, Guido; Daubenberger, Claudia (BMC Biotechnology, 2015-05)

  Abstract Background: Conventionally, human monocyte sub-populations are classified according to surface marker expression into classical (CD14++CD16−), intermediate (CD14++CD16+) and non-classical (CD14+CD16++) lineages. ...
• The Contribution of Host Cells to Pneumocystis Immunity: An Update Contribution 

  Otieno-Odhiambo, Patricia; Wasserman, Sean; Hoving, J. Claire (mdpi, 2019-04-19)

  Abstract: Pneumocystis is a ubiquitous atypical fungus that is distributed globally. The genus comprises morphologically similar but genetically heterogeneous species that have co-evolved with specific mammalian hosts ...
• Prevalence and Concentration of Lead (Pb) and Cadmium (Cd) in Kales (Brassica oleracea Acephala) & Spinach (Spinacia oleracea) Sold at Masaku County, Kenya 

  Orina, Alfred Isaac; Mutua, Mutuku Joseph; Adawo, Onjong Hillary; Wanjiru, Mwaniki Mercy; Reagan, Vuluku; Venessa, Muchai (International Journal of Food Science and Biotechnology, 2020-11-09)

  Abstract: Background: Exposure to heavy metals (Pb and Cd) through diet posses a significant risk to human health. Areas of Mlolongo, Athi River and Syokimau are surrounded by industries, which dispose off their waste water ...
• Sex-specific induction of CYP6 cytochrome P450 genes in cadmium and lead tolerant Anopheles gambiae 

  Orina, Alfred Isaac; Musasia, Fauzia K; Masiga2, Daniel K; Omedo, Irene A; Mwakubambanya, Ramadhan; Ochieng, Richard; Mireji, Paul O (Malaria Journal, 2013-05)

  Abstract Background: Anopheles gambiae, one of the main Afro-tropical mosquito vector of malaria, has adapted to heavy metals in its natural habitat, and developed resistance to most conventional insecticides. Investigations ...
• Coenzyme Q10 prevented full blown splenomegaly and decreased melarsoprol-induced reactive encephalopathy in mice infected with Trypanosoma brucei rhodesiense 

  Orina, Alfred Isaac; Nyariki, James Nyabuga; Thuita, John Kibuthu; Nyambati, Grace Kemunto (Journal of Coastal Life Medicine, 2014-03-14)

  Objective: To establish the modulatory effects of coenzyme Q10 on experimental trypanosome itnrefeactmtioennst riena cmtiivcee eanncde epvhaalluoaptaet hthy e(P rTiRskE )o.f occurrence and severity of melarsoprol-induced ...
• Oral Administration of Coenzyme Q10 has the Capacity to Stimulate Innate Lymphoid Cells Class Two during Experimental Cerebral Malaria 

  Unknown author (2019-01-30)

  Cerebral malaria is a complex neurological syndrome, whose pathology is mediated by inflammatory processes triggered by the immune system of the host following infection with P. falciparum. Coenzyme Q10 (CoQ10) is an ...
• Metabolic and Antioxidant System Alterations in an Astrocytoma Cell Line Challenged with Mitochondrial DNA Deletion 

  Orina, Alfred Isaac; Dukhande, Vikas V.; Lai, James C. K. (Springer Science, 2007-06-12)

  Abstract Oxidative stress can induce mitochondrial dysfunction, mitochondrial DNA (mtDNA) depletion, and neurodegeneration, although the underlying mechanisms are poorly understood. The major mitochondrial antioxidant ...
• Effects of Continuous Hypoxia on Energy Metabolism in Cultured Cerebro-Cortical Neurons 

  Orina, Alfred Isaac; Malthankar-Phatak, Gauri H.; Patel, Anant B. (nATIONAL iNSTITUTE OF hEALTH, 2008-10)

  Abstract Mechanisms underlying hypoxia-induced neuronal adaptation have not been fully elucidated. In the present study we investigated glucose metabolism and the activities of glycolytic and TCA cycle enzymes in ...
• Metabolic and Antioxidant System Alterations in an Astrocytoma Cell Line Challenged with Mitochondrial DNA Deletion 

  Orina, Alfred Isaac; Vikas, V.; Lai, James C. K. (Springer Science, 2007-06-12)

  Abstract Oxidative stress can induce mitochondrial dysfunction, mitochondrial DNA (mtDNA) depletion, and neurodegeneration, although the underlying mechanisms are poorly understood. The major mitochondrial antioxidant ...
• Manganese Treatment Modulates the Expression of Peroxisome Proliferator-activated Receptors in Astrocytoma and Neuroblastoma Cells 

  Orina, Alfred Isaac; Kawikova, Ivana; Alfred, L.; Bothwell, M. (Springer Science, 2006-10-20)

  Abstract Peroxisome proliferator-activated receptors (PPARs) play roles in neural cells by regulating energy balance, cell proliferation and anti-oxidant responses although the molecular mechanisms underlying such roles ...
• Antifungal activity of crude tea extracts 

  Orina, Alfred Isaac; Koech, K. R.; Wachira, F. N.; Ngure, R. M. (AFRICAN JOURNAL OF AGRICULTURAL RESEARCH, 2013-05-23)

  The tea polyphenols have been shown to possess many medicinal properties including antifungal activity, but there have been few studies regarding antifungal activity. The antifungal activity of tea polyphenols was evaluated ...
• Coenzyme Q10 nullified khat-induced hepatotoxicity, nephrotoxicity and inflammation in a mouse model 

  Orina, Alfred Isaac; Kennedy, Chepukosi; Okanya, Patrick; Nyariki, James Nyabuga (www.sciencedirect.com/science/journal/24058440, 2020-05-19)

  Ethnopharmacological relevance: The consumption of khat (Catha Edulis, Forsk) is on the rise despite the much publicized associated deleterious health effects. How chemicals present in khat, affect various physiological ...
• Abnormal Brain Iron Homeostasis in Human and Animal Prion Disorders 

  Orina, Alfred Isaac; Singh, Ajay; Luo, Xiu (PLOS Pathogens, 2009-03-13)

  Abstract Neurotoxicity in all prion disorders is believed to result from the accumulation of PrP-scrapie (PrPSc), a b-sheet rich isoform of a normal cell-surface glycoprotein, the prion protein (PrPC). Limited reports ...
• Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3- dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice 

  Orina, Alfred Isaac; Mwaeni, Victoria K.; Nyariki, James N.; Jillani, Ngalla; Omwenga, George; Ngugi, Mathew (BMC Pharmacology and Toxicology, 2021-03)

  Abstract Background: Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by ...
• Nutrition Status of Children in Orphanages in Selected Primary Schools within Dagoretti Division Nairobi, Kenya 

  Mwaniki, Elizabeth; MAKOKHA, A. N. (Nutrition & Food Sciences, 2013-12)

  Abstract Background: School-age children are particularly vulnerable to under nutrition as the priority in nutrition interventions is often to prevent malnutrition during fetal development and the first years of life. ...
• Comparison of risk factors between people with type 2 diabetes and matched controls in Nairobi, Kenya 

  Mwaniki, Elizabeth; Manyara, Anthony Muchai (Tropical Medicine and International Health, 2021-09)

  Objective To identify risk factors associated with type 2 diabetes (T2D) in Nairobi, Kenya. methods A case–control study comparing 70 (53% women) recently diagnosed T2D cases with age-, sex- and socioeconomic status-matched ...
• NUTRITION STATUS AND ASSOCIATED MORBIDITY RISK FACTORS AMONG ORPHANAGE AND NON-ORPHANAGE CHILDREN IN SELECTED PUBLIC PRIMARY SCHOOLS WITHIN DAGORETTI, NAIROBI, KENYA 

  Mwaniki, Elizabeth; MAKOKHA, A.N.; MUTTUNGA, J. N. (East African Medical Journal, 2014-09)

  ABSTRACT Background: Most of the nutritional surveys that have been carried out in Kenya have concentrated on children aged five years and below who are under the care of their parent(s). The HIV/AIDS, conflict, natural ...
• Sustenance of HIV/STI Protective Behaviours by Slum Dwelling Adolescent Girls and Young Women in Associated with their Income Status 

  Mwaniki, Elizabeth W.; Nguku, Julius N.; Muia, Tabitha; Mbai, Fiona N. (2018-12-12)

  The burden of HIV and AIDS in Sub-saharan Africa continues to be the highest among all the regions in the world constituting about 70% of the 6,000 new infections that occur globally daily. In Kenya, while there has been ...

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