• In vitro Anti-plasmodial Activity of Rubia cordifolia, Harrizonia abyssinica, Leucas calostachys Olive and Sanchus schweinfurthii Medicinal Plants. 

  Nyambati, GK; Lagat, ZO; Maranga, RO; Samuel, M; Ozwara, H (2013)

  Plasmodium falciparum is becoming increasingly resistant to conventional antimalaria drugs. Rapid increase of parasite resistant strains, resistance of the vector to insecticides and the difficulty in creating efficient ...
• Coenzyme Q10 prevented full blown splenomegaly and decreased melarsoprol-induced reactive encephalopathy in mice infected with Trypanosoma brucei rhodesiense 

  Nyariki, James Nyabuga; Thuita, John Kibuthu; Nyambati, Grace Kemunto; Isaac, Alfred Orina (2014)

  Objective: To establish the modulatory effects of coenzyme Q10 on experimental trypanosome infections in mice and evaluate the risk of occurrence and severity of melarsoprol-induced post treatment reactive encephalopathy ...
• Evaluation of the Anticonvulsant Activity of the Leaf Methanol Extract of Crassula arborescens (Mill.) Willd. (Crassulaceae) in Mice 

  Amabeoku, George Jimboyeka; Mbamalu, Oluchi Nneka; Davids, Tasneem; Fakude, Samukelisiwe; Gqwaka, Anda; Mbai, Fiona N; Pieterse, Reighman; Shaik, Aneesa (2014)

  Crassula arborescens (Mill.) Willd. subsp. Arborescens is widely used for the treatment of various ailments including diarrhoea, corns, epilepsy and as a purgati ve. However, no information exists in any literature ...
• Reply to “Letter to the Editor: ‘Understanding the WHI gap’ 

  Pechenino, Angela S; Lee, Alison R; Lin, Li; Mbai, Fiona N; Stallone, John N; Knowlton, AA (2012)

  This is a reply in response to Drs. Kerber's and Turner's commentary about our article (10) in Physiological Genomics. We thank Kerber and Turner for their enthusiastic response to our article and are pleased that they ...
• Efforts to identify early spontaneous embryo mortality in the rhesus monkey (Macaca mulatta) 

  Mbai, Fiona N (1989)
• Rapid Activation of Nuclear Factor-κB by 17β-Estradiol and Selective Estrogen Receptor Modulators: Pathways Mediating Cellular Protection 

  Stice, James P; Mbai, Fiona N; Chen, Le; Knowlton, Anne A (2012)

  17 β -estradiol (E2) treatment activates a set of protective response that have been found to protect cells from injury and more importantly to significantly abate the injuries associated with trauma- hemorrhage in ...
• Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation 

  Pechenino, Angela S; Lin, Li; Mbai, Fiona N; Lee, Alison R; He, Xian-Min; Stallone, John N; Knowlton, AA (2011)

  Despite an abundance of evidence to the contrary from animal studies, large clinical trials on humans have shown that estrogen administered to postmenopausal women increases the risk of cardiovascular disease. However, ...
• Deciphering the reproductive protein-protein interaction network in Anopheles gambiae with Drosophila melanogaster as a framework 

  Achinko, Daniel; Mireji, Paul O; Catteruccia, Flaminia; Masiga, Dan (2011)

  Protein-protein interactions (PPIs) are the most fundamental biological processes at the molecular level. The experimental methods for testing PPIs are time-consuming and are limited by analogs for many reactions. As a ...
• Life stage and tissue speciation of cathepsin B (AGAP004533) derives different functional properties in the G3 strain of the mosquito Anopheles gambiae 

  Achinko, Daniel; Masiga, Dan; Mireji, Paul O; Catteruccia, Flaminia (2012)

  Cathepsin B is a lysosomal papain-like cysteine peptidase that is expressed in all tissues and functions primarily as an exopeptidase through its carboxydipeptidyl activity. Together with other cathepsins, it is involved ...
• Chemosensory receptors in tsetse flies provide link between chemical and behavioural ecology 

  Masiga, Daniel; Obiero, George; Macharia, Rosaline; Mireji, Paul O; Christoffels, Alan (2014)

  Tsetse flies survive in a variety of environments across tropical Africa, often rising to large numbers, despite their low birth rate of one offspring every seven to nine days. They use olfactory receptors to process ...
• RESEARCH Open Access High-resolution melting analysis reveals low Plasmodium parasitaemia infections among microscopically negative febrile patients in western Kenya 

  Kipanga, Purity N; Omondi, David; Mireji, Paul O; Sawa, Patrick; Masiga, Daniel K; Villinger, Jandouwe (2014)

  Background: Microscopy and rapid diagnostic tests (RDTs) are common tools for diagnosing malaria, but are deficient in detecting low Plasmodium parasitaemia. A novel molecular diagnostic tool (nPCR-HRM) that combines the ...
• Polyphenolic composition and antioxidant activity of Kenyan Tea cultivars 

  Karori, SM; Wachira, FN; Ngure, RM; Mireji, PO (2014)

  Polyphenolic fractions in tea are potent bioactive mo lecules. In this study, the polyphenolic composition of 25 different types of Kenyan tea cultivars was de termined using the HPLC and the Folins Ciocalteus ...
• Blood Meal Analysis and Virus Detection in Blood-Fed Mosquitoes Collected During the 2006–2007 Rift Valley Fever Outbreak in Kenya 

  Lutomiah, Joel; Omond, David; Masiga, Daniel; Mutai, Collins; Mireji, Paul O; Ongus, Juliette; Linthicum, Ken J; Sang, Rosemary (2014)

  Background: Rift Valley fever (RVF) is a zoonosis of domestic ruminants in Africa. Blood-fed mosquitoes collected during the 2006–2007 RVF outbreak in Kenya were analyzed to determine the virus infection status and animal ...
• Field Responses of Tsetse Flies (Glossinidae) and Other Diptera to Oils in Formulations of Deltamethrin 

  Mireji, PO; Mabveni, AM; Dube, BN; Ogembo, JG; Matoka, CM; Mangwiro, TNC (2003)

  Investigations were conducted to establish field responses of Glossina pallidipes, G. m. morsitans, muscoids and tabanids to castor, raw linseed, paraffin and chlorinated paraffin oils in deltamethrin suspension concentrate ...
• RESEARCH Open Access Sex-specific induction of CYP6 cytochrome P450 genes in cadmium and lead tolerant Anopheles gambiae 

  Musasia, Fauzia K; Isaac, Alfred O; Masiga, Daniel K; Omedo, Irene A; Ochieng, Richard; Mireji, Paul O; Mwakubambanya, Ramadhan (2013)

  Background: Anopheles gambiae, one of the main Afro-tropical mosquito vector of malaria, has adapted to heavy metals in its natural habitat, and developed resistance to most conventional insecticides. Investigations ...
• Expression of metallothionein and [alpha]-tubulin in heavy metal-tolerant 

  Mireji, PO; Keating, J; Hassanali, A; Impoinvil, DE; Mbogo, CM; Muturi, MN; Nyambaka, H; Kenya, EU; Githure, JI; Beier, JC (2010)
• Expression of metallothionein and α-tubulin in heavy metal-tolerant Anopheles gambiae sensu stricto (Diptera: Culicidae) 

  Mireji, Paul O; Keating, Joseph; Hassanali, Ahmed; Impoinvil, Daniel E; Mbogo, Charles M; Muturi, Martha N; Nyambaka, Hudson; Kenya, Eucharia U; Githure, John I; Beier, John C (2010)

  Anopheles mosquitoes have been shown to adapt to heavy metals in their natural habitats. In this study we explored the possibility of using Anopheles gambiae sensu stricto as bio-reporters for environmental heavy metal ...
• Biological cost of tolerance to heavy metals in the mosquito Anopheles gambiae 

  Mireji, PO; Keating, J; Hassanal, A; Mbogo, CM; Muturi, MN; Githure, JI; Beier, JC (2010)

  The global rate of heavy metal pollution is rapidly increasing in various habitats. Anopheles malaria vector species (Diptera: Culicidae) appear to tolerate many aquatic habitats with metal pollutants, despite their normal ...
• Changes in genotypes of Plasmodium falciparum human malaria parasite following withdrawal of chloroquine in Tiwi, Kenya 

  Mang’era, Clarence M.; Mbai, Fiona N; Omedo, Irene A; Mireji, Paul O; Omar, Sabah A (Elsevier, 2012)

  Chloroquine (CQ) drug was withdrawn in 1998 as a first-line treatment of uncomplicated malaria in Kenya. This was in response to resistance to the drug in Plasmodium falciparum malaria parasite. Investigations were conducted ...
• A Novel Highly Divergent Protein Family Identified from a Viviparous Insect by RNA-seq Analysis: A Potential Target for Tsetse Fly-Specific Abortifacients 

  Benoit, Joshua B.; Attardo, Geoffrey M; Michalkova, Veronika; Krause, Tyler B; Bohova, Jana; Zhang, Qirui; Baumann, Aaron A; Mireji, PO; Takáč, Peter; Denlinger, David L; Ribeiro, Jose M; Aksoy, Serap (2014)

  In tsetse flies, nutrients for intrauterine larval development are synthesized by the modified accessory gland (milk gland) and provided in mother's milk during lactation. Interference with at least two milk proteins has ...

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